Products

Western Blot

Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with KTN1 polyclonal antibody (Cat # PAB20173) at 1:250-1:500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human testis with KTN1 polyclonal antibody (Cat # PAB20173) shows strong cytoplasmic positivity in cells of seminiferus ducts at 1:50-1:200 dilution.

Immunofluorescence

Immunofluorescent staining of human cell line U-251 MG with KTN1 polyclonal antibody (Cat # PAB20173) at 1-4 ug/mL dilution shows positivity in endoplasmic reticulum.

Entrez GeneID

3895

Protein Accession#

Q86UP2

Gene Name

KTN1

Gene Alias

CG1, KIAA0004, KNT, MGC133337, MU-RMS-40.19

Gene Description

kinectin 1 (kinesin receptor)

Omim ID

600381

Gene Ontology

Hyperlink

Gene Summary

Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin (see MIM 148760 and MIM 600025), an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin.[supplied by OMIM

Other Designations

CG-1 antigen|OTTHUMP00000179010|OTTHUMP00000179011|OTTHUMP00000179012|kinectin 1|kinesin receptor