PKM2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PKM2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PKM2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The PKM2 polyclonal antibody (Cat # PAB2017) is used in Western blot to detect PKM2 in HeLa cell lysate (Lane 1) and NIH/3T3 cell lysate (Lane 2) . -
Gene Info — PKM2
Entrez GeneID
5315Protein Accession#
NP_002645;P14786Gene Name
PKM2
Gene Alias
CTHBP, MGC3932, OIP3, PK3, PKM, TCB, THBP1
Gene Description
pyruvate kinase, muscle
Omim ID
179050Gene Ontology
HyperlinkGene Summary
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq
Other Designations
OPA-interacting protein 3|PK, muscle type|pyruvate kinase M2|thyroid hormone-binding protein, cytosolic
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Interactome
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Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Carbon fixation in photosynthetic organisms
- Glycolysis / Gluconeogenesis
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Disease
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Publication Reference
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Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.
Williams JM, Chen GC, Zhu L, Rest RF.
Molecular Microbiology 1998 Jan; 27(1):171.
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A pancreatic cancer-specific expression profile.
Gress TM, Muller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Buchler M, Adler G, Lehrach H.
Oncogene 1996 Aug; 13(8):1819.
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Isolation and characterization of the human pyruvate kinase M gene.
Takenaka M, Noguchi T, Sadahiro S, Hirai H, Yamada K, Matsuda T, Imai E, Tanaka T.
European Journal of Biochemistry 1991 May; 198(1):101.
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Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.
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