Products

Western Blot

Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with PPFIBP1 polyclonal antibody (Cat # PAB20099) at 1:250-1:500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human skin with PPFIBP1 polyclonal antibody (Cat # PAB20099) shows moderate cytoplasmic positivity in epidermal cells and adnexal cells at 1:200-1:500 dilution.

Entrez GeneID

8496

Protein Accession#

Q86W92

Gene Name

PPFIBP1

Gene Alias

L2, hSGT2, hSgt2p

Gene Description

PTPRF interacting protein, binding protein 1 (liprin beta 1)

Omim ID

603141

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Other Designations

PTPRF interacting protein binding protein 1|liprin related protein|liprin-beta 1|protein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1