GRM5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRM5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus residues surrounding T1003 of human GRM5.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse brain tissue lysate (35 ug/lane) with GRM5 polyclonal antibody (Cat # PAB2007). -
Gene Info — GRM5
Entrez GeneID
2915Protein Accession#
NP_000833;P41594-2Gene Name
GRM5
Gene Alias
GPRC1E, MGLUR5, mGlu5
Gene Description
glutamate receptor, metabotropic 5
Omim ID
604102Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
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Publication Reference
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Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.
Pacheco R, Ciruela F, Casado V, Mallol J, Gallart T, Lluis C, Franco R.
The Journal of Biological Chemistry 2004 Aug; 279(32):33352.
Application:Flow Cyt, IF, Human, Human lymphocytes, Jurkat, SKW6.4 cells.
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Differential expression of mGluR5 in human lumbosacral motoneurons.
Anneser JM, Ince PG, Shaw PJ, Borasio GD.
Neuroreport 2004 Feb; 15(2):271.
Application:IHC-Fr, Human, Human spinal cord tissues.
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Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC.
Uchino M, Sakai N, Kashiwagi K, Shirai Y, Shinohara Y, Hirose K, Iino M, Yamamura T, Saito N.
The Journal of Biological Chemistry 2004 Jan; 279(3):2254.
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Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.
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