Products

Western Blot (Cell lysate)

Western blot analysis of cell lysates with CCDC50 polyclonal antibody (Cat # PAB20051) at 1:250-1:500 dilution.
Lane 1 : NIH/3T3
Lane 2 : NBT-II

Western Blot

Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: A-431, Lane 4: Liver, Lane 5: Tonsil with CCDC50 polyclonal antibody (Cat # PAB20051) at 1:250-1:500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human lymph node with CCDC50 polyclonal antibody (Cat # PAB20051) shows strong cytoplasmic positivity in a subset of lymphoid cells outside reaction center at 1:1000-1:2500 dilution.

Immunofluorescence

Immunofluorescent staining of human cell line U-251 MG with CCDC50 polyclonal antibody (Cat # PAB20051) at 1-4 ug/mL dilution shows positivity in cytoplasm.

Entrez GeneID

152137

Protein Accession#

Q8IVM0

Gene Name

CCDC50

Gene Alias

C3orf6, DFNA44, YMER

Gene Description

coiled-coil domain containing 50

Omim ID

607453 611051

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq

Other Designations

Ymer protein