Products

Western Blot (Transfected lysate)

Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells with KCND1 polyclonal antibody (Cat # PAB20029).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human pancreas with KCND1 polyclonal antibody (Cat # PAB20029) shows moderate cytoplasmic positivity in Islet cells.

Entrez GeneID

3750

Protein Accession#

Q9NSA2

Gene Name

KCND1

Gene Alias

KV4.1

Gene Description

potassium voltage-gated channel, Shal-related subfamily, member 1

Omim ID

300281

Gene Ontology

Hyperlink

Gene Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle. [provided by RefSeq

Other Designations

OTTHUMP00000025805|shal-type potassium channel|voltage-gated potassium channel Kv4.1