Products

Western Blot (Transfected lysate)

Western blot analysis of Lane 1: Negative control (vector only transfected HEK293T lysate), Lane 2: Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells with TPM1 polyclonal antibody (Cat # PAB19961).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human smooth muscle with TPM1 polyclonal antibody (Cat # PAB19961) shows moderate cytoplasmic positivity in smooth muscle cells.

Entrez GeneID

7168

Protein Accession#

P09493

Gene Name

TPM1

Gene Alias

C15orf13, CMD1Y, HTM-alpha, TMSA

Gene Description

tropomyosin 1 (alpha)

Omim ID

115196 191010

Gene Ontology

Hyperlink

Gene Summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq

Other Designations

alpha tropomyosin|cardiomyopathy, hypertrophic 3|sarcomeric tropomyosin kappa|tropomyosin 1 alpha chain