OTC polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of Lane 1: RT-4, Lane 2: EFO-21, Lane 3: A-431, Lane 4: Liver, Lane 5: Tonsil with OTC polyclonal antibody (Cat # PAB19959) at 1:250-1:500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human liver with OTC polyclonal antibody (Cat # PAB19959) shows cytoplasmic positivity in hepatocytes.
Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with OTC polyclonal antibody (Cat # PAB19959) at 1-4 ug/mL dilution shows positivity in mitochondria.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant OTC.
Immunogen
Recombinant protein corresponding to amino acids 172-299 of human OTC.
Sequence
ILADYLTLQEHYSSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDASVTKLAEQYAKENGTKLLLTNDPLEAAHGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAASDWT
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:250-1:500)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: RT-4, Lane 2: EFO-21, Lane 3: A-431, Lane 4: Liver, Lane 5: Tonsil with OTC polyclonal antibody (Cat # PAB19959) at 1:250-1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human liver with OTC polyclonal antibody (Cat # PAB19959) shows cytoplasmic positivity in hepatocytes.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with OTC polyclonal antibody (Cat # PAB19959) at 1-4 ug/mL dilution shows positivity in mitochondria. -
Gene Info — OTC
Entrez GeneID
5009Protein Accession#
P00480Gene Name
OTC
Gene Alias
MGC129967, MGC129968, MGC138856, OCTD
Gene Description
ornithine carbamoyltransferase
Gene Ontology
HyperlinkGene Summary
This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also. [provided by RefSeq
Other Designations
OTTHUMP00000024343|ornithine transcarbamylase
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Interactome
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Pathway
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Disease
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