TNNC1/TNNC2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against native TNNC1/TNNC2.
Immunogen
Native purified TNNC1/TNNC2 from human skeletal muscle.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.5 (0.02% sodium azide, 50% glycerol (v/v))
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme Immunoassay
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Gene Info — TNNC2
Entrez GeneID
7125Gene Name
TNNC2
Gene Alias
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Gene Description
troponin C type 2 (fast)
Omim ID
191039Gene Ontology
HyperlinkGene Summary
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq
Other Designations
OTTHUMP00000039531|fast skeletal muscle troponin C|troponin C2, fast
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Gene Info — TNNC1
Entrez GeneID
7134Gene Name
TNNC1
Gene Alias
CMD1Z, TNC, TNNC
Gene Description
troponin C type 1 (slow)
Omim ID
191040Gene Ontology
HyperlinkGene Summary
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq
Other Designations
cardiac troponin C|slow twitch skeletal/cardiac muscle troponin C|troponin C, slow|troponin C1, slow
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Interactome
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Disease
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