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F13A1/F13A2/F13A3/F13B polyclonal antibody

  • Catalog # : PAB19873
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against native F13A1/F13A2/F13A3/F13B.
  • Immunogen:
  • Native purified F13A1/F13A2/F13A3/F13B from human plasma.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.5 (0.02% sodium azide, 50% glycerol (v/v))
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Enzyme Immunoassay
  • Application Image
  • Western Blot
  • Enzyme Immunoassay
  • Gene Information
  • Entrez GeneID:
  • 2162
  • Gene Name:
  • F13A1
  • Gene Alias:
  • F13A
  • Gene Description:
  • coagulation factor XIII, A1 polypeptide
  • Gene Summary:
  • This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq
  • Other Designations:
  • FSF, A subunit,TGase,bA525O21.1 (coagulation factor XIII, A1 polypeptide),coagulation factor XIII A1 subunit,coagulation factor XIII, A polypeptide,factor XIIIa,fibrin stabilizing factor, A subunit,fibrinoligase,protein-glutamine gamma-glutamyltransferase
  • Gene Information
  • Entrez GeneID:
  • 2163
  • Gene Name:
  • F13A2
  • Gene Alias:
  • -
  • Gene Description:
  • coagulation factor XIII, A2 polypeptide
  • Other Designations:
  • -
  • Gene Information
  • Entrez GeneID:
  • 2164
  • Gene Name:
  • F13A3
  • Gene Alias:
  • -
  • Gene Description:
  • coagulation factor XIII, A3 polypeptide
  • Other Designations:
  • -
  • Gene Information
  • Entrez GeneID:
  • 2165
  • Gene Name:
  • F13B
  • Gene Alias:
  • FXIIIB
  • Gene Description:
  • coagulation factor XIII, B polypeptide
  • Gene Summary:
  • This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000034674,TGase,coagulation factor XIII B subunit
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