NOTCH2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of human fetal brain with NOTCH2 polyclonal antibody (Cat # PAB19843) at 1:500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human brain showing staining with NOTCH2 polyclonal antibody (Cat # PAB19843) at 1:100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NOTCH2.
Immunogen
A synthetic peptide corresponding to amino acids 1719-1733 of human NOTCH2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:160000)
Western Blot (1:500-1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of human fetal brain with NOTCH2 polyclonal antibody (Cat # PAB19843) at 1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human brain showing staining with NOTCH2 polyclonal antibody (Cat # PAB19843) at 1:100 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NOTCH2
Entrez GeneID
4853Protein Accession#
Q04721Gene Name
NOTCH2
Gene Alias
AGS2, hN2
Gene Description
Notch homolog 2 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. [provided by RefSeq
Other Designations
OTTHUMP00000014035|OTTHUMP00000059536|notch 2
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Interactome
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Pathway
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Disease
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