PRKAA2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of mouse liver tissue lysate with PRKAA2 polyclonal antibody (Cat # PAB19814) at 1:500 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PRKAA2.
Immunogen
A synthetic peptide corresponding to 16 amino acids at internal region of human PRKAA2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:20000-80000)
Western Blot (1:200-1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse liver tissue lysate with PRKAA2 polyclonal antibody (Cat # PAB19814) at 1:500 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PRKAA2
Entrez GeneID
5563Protein Accession#
P54646Gene Name
PRKAA2
Gene Alias
AMPK, AMPK2, PRKAA
Gene Description
protein kinase, AMP-activated, alpha 2 catalytic subunit
Omim ID
600497Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq
Other Designations
5'-AMP-activated protein kinase, catalytic alpha-2 chain|AMP-activated protein kinase alpha 2 catalytic subunit|AMPK-alpha-2 chain|OTTHUMP00000009993
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