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Last updated: 2017/10/22

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ANK1 polyclonal antibody

  • Catalog # : PAB19795
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of ANK1.
  • Immunogen:
  • A synthetic peptide corresponding to 15 amino acids near C-terminus of human ANK1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Recommend Usage:
  • ELISA (1:20000-1:80000)
    Western Blot (1:200-500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In serum (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of human fetal muscle tissue lysate with ANK1 polyclonal antibody (Cat # PAB19795) at 1:500 dilution.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 286
  • Gene Name:
  • ANK1
  • Gene Alias:
  • ANK,SPH1,SPH2
  • Gene Description:
  • ankyrin 1, erythrocytic
  • Gene Summary:
  • Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq
  • Other Designations:
  • ankyrin 1,ankyrin-1, erythrocytic,ankyrin-R
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