TGFBR1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TGFBR1.
Immunogen
A synthetic peptide correspoding to amino acids 50-63 at internal region of human TGFBR1.
Sequence
TDGLCFVSVTETTD
Host
Goat
Theoretical MW (kDa)
55.6
Reactivity
Mouse, Rat
Specificity
This antibody is expected to recognize both reported isoforms (NP_004603.1; NP_001124388.1). The immunizing peptide represents part of a potential extracellular domain.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TGFBR1 polyclonal antibody (Cat # PAB19758) (0.1 ug/mL) staining of rat liver tissue lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TGFBR1
Entrez GeneID
7046Protein Accession#
NP_004603.1;NP_001124388.1Gene Name
TGFBR1
Gene Alias
AAT5, ACVRLK4, ALK-5, ALK5, LDS1A, LDS2A, SKR4, TGFR-1
Gene Description
transforming growth factor, beta receptor 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000021783|activin A receptor type II-like kinase, 53kD|activin A receptor type II-like kinase, 53kDa|activin receptor-like kinase 5|serine/threonine-protein kinase receptor R4|transforming growth factor beta receptor I|transforming growth factor,
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Interactome
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Pathway
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Disease
- Abnormalities
- Adenocarcinoma
- Adenoma
- Aneurysm
- Aortic Aneurysm
- Aortic Rupture
- Asthma
- Atherosclerosis
- Behcet Syndrome
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