AIRE polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AIRE.
Immunogen
A synthetic peptide corresponding to 15 amino acids at C-terminus of human AIRE.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:80000)
Western Blot (1:200-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of human thymus (Lane 1) and human testis (Lane 2) tissue lysate with AIRE polyclonal antibody (Cat # PAB19745) at 1:500 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AIRE
Entrez GeneID
326Protein Accession#
O43918Gene Name
AIRE
Gene Alias
AIRE1, APECED, APS1, APSI, PGA1
Gene Description
autoimmune regulator
Gene Ontology
HyperlinkGene Summary
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). [provided by RefSeq
Other Designations
autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
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Interactome
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Pathway
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Disease
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Publication Reference
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PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator–dependent autoimmunity.
Mathieu AL, Verronese E, Rice GI, Fouyssac F, Bertrand Y, Picard C, Chansel M, Walter JE, Notarangelo LD, Butte MJ, Nadeau KC, Csomos K, Chen DJ, Chen K, Delgado A, Rigal C, Bardin C, Schuetz C, Moshous D, Reumaux H, Plenat F, Phan A, Zabot MT, Balme B, Viel S, Bienvenu J, Cochat P, van der Burg M, Caux C, Kemp EH, Rouvet I, Malcus C, Meritet JF, Lim A, Crow YJ, Fabien N, Menetrier-Caux C, De Villartay JP, Walzer T, Belot A.
The Journal of Allergy and Clinical Immunology 2015 Jun; 135(6):1578.
Application:WB-Tr, Human, Skin fibroblasts.
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PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator–dependent autoimmunity.
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