HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human EPM2AIP1 with DYKDDDDK tag probed with EPM2AIP1 polyclonal antibody (Cat # PAB19709) (1 ug/mL) in lane 1 and probed with anti-DYKDDDDK Tag (1/1000) in lane 3. Mock-transfected HEK293 probed with EPM2AIP1 polyclonal antibody (Cat # PAB19709) (1 mg/mL) in lane 2. Primary incubations were for 1 hour. Detected by chemiluminescence.
The EPM2A gene, which encodes laforin, is mutated in an autosomal recessive form of adolescent progressive myoclonus epilepsy. The protein encoded by this gene binds to laforin, but its function is not known. This gene is intronless. [provided by RefSeq