SPG20 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
SPG20 polyclonal antibody (Cat # PAB19701) (2 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunocytochemistry
SPG20 polyclonal antibody (Cat # PAB19701) (2 ug/mL) staining of methanol-fixed HeLa before (upper) and after (bottom) introduction of siRNA.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SPG20.
Immunogen
A synthetic peptide corresponding to internal region of human SPG20.
Sequence
C-EASGTDVKQLDQGNK
Host
Goat
Theoretical MW (kDa)
72.8
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
SPG20 polyclonal antibody (Cat # PAB19701) (2 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunocytochemistry
SPG20 polyclonal antibody (Cat # PAB19701) (2 ug/mL) staining of methanol-fixed HeLa before (upper) and after (bottom) introduction of siRNA.Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SPG20
Entrez GeneID
23111Protein Accession#
NP_055902.1Gene Name
SPG20
Gene Alias
KIAA0610, SPARTIN, TAHCCP1
Gene Description
spastic paraplegia 20 (Troyer syndrome)
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq
Other Designations
OTTHUMP00000018254|spartin|spastic paraplegia 20, spartin (Troyer syndrome)|spastic paraplegia autosomal recessive Troyer syndrome|trans-activated by hepatitis C virus core protein 1
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Interactome
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Disease
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