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Last updated: 2017/5/21
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SPG20 polyclonal antibody

  • Catalog # : PAB19701
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of SPG20.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human SPG20.
  • Sequence:
  • C-EASGTDVKQLDQGNK
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 72.8
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Recommend Usage:
  • ELISA (1:8000)
    Western Blot (1-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • SPG20 polyclonal antibody (Cat # PAB19701) (2 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • Immunocytochemistry
  • Immunocytochemistry
  • SPG20 polyclonal antibody (Cat # PAB19701) (2 ug/mL) staining of methanol-fixed HeLa before (upper) and after (bottom) introduction of siRNA.
  • Immunofluorescence
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunofluorescence
  • ELISA
  • Gene Information
  • Gene Name:
  • SPG20
  • Gene Alias:
  • KIAA0610,SPARTIN,TAHCCP1
  • Gene Description:
  • spastic paraplegia 20 (Troyer syndrome)
  • Gene Summary:
  • This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000018254,spartin,spastic paraplegia 20, spartin (Troyer syndrome),spastic paraplegia autosomal recessive Troyer syndrome,trans-activated by hepatitis C virus core protein 1
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