SLC46A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
SLC46A1 polyclonal antibody (Cat # PAB19698) (0.3 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SLC46A1.
Immunogen
A synthetic peptide corresponding to amino acids 233-247 at internal region of human SLC46A1.
Sequence
C-LKEPKSTRLFTFRH
Host
Goat
Theoretical MW (kDa)
49.8
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SLC46A1 polyclonal antibody (Cat # PAB19698) (0.3 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SLC46A1
Entrez GeneID
113235Protein Accession#
NP_542400.2Gene Name
SLC46A1
Gene Alias
HCP1, MGC9564, PCFT
Gene Description
solute carrier family 46 (folate transporter), member 1
Omim ID
611672Gene Ontology
HyperlinkGene Summary
This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a transmembrane heme transporter in duodenal enterocytes and, potentially, in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene cause the autosomal recessive hereditary folate malabsorption (HFM) disease. HFM is characterized by folate deficiency due to reduced intestinal folate absorption and subsequent anemia, hypoimmunoglobulinemia, and recurrent infections. [provided by RefSeq
Other Designations
heme carrier protein 1|proton-coupled folate transporter|solute carrier family 46, member 1
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Interactome
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Disease
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