NFASC polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
NFASC polyclonal antibody (Cat # PAB19682) (0.5 ug/mL) staining of human lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NFASC.
Immunogen
A synthetic peptide corresponding to amino acids 877-890 at internal region of human NFASC.
Sequence
C-NFSPNQTKFTVQRT
Host
Goat
Theoretical MW (kDa)
138
Reactivity
Human, Rat
Specificity
This antibody is expected to recognize reported isoforms 1, 2, 3 and 4 (NP_001005388.2;,NP_001153803.1, NP_001153804.1and NP_055905.2 resp).
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
NFASC polyclonal antibody (Cat # PAB19682) (0.5 ug/mL) staining of human lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NFASC
Entrez GeneID
23114Protein Accession#
NP_001005388.2;NP_001153803.1;NP_001153804.1;NP_055905.2Gene Name
NFASC
Gene Alias
DKFZp686P2250, FLJ46866, KIAA0756, NF, NRCAML
Gene Description
neurofascin homolog (chicken)
Omim ID
609145Gene Ontology
HyperlinkGene Summary
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined
Other Designations
OTTHUMP00000065305|OTTHUMP00000065306|OTTHUMP00000065307|OTTHUMP00000065308|OTTHUMP00000065313|OTTHUMP00000065315|OTTHUMP00000065321|OTTHUMP00000065322|OTTHUMP00000065324|neurofascin
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Interactome
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Pathway
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Disease
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