GM2A polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human GM2A with DYKDDDDK tag probed with GM2A polyclonal antibody (Cat # PAB19672) (1.0 ug/mL) in lane 1 and probed with anti- DYKDDDDK Tag (1/30000) in lane 3. Mock-transfected HEK293 probed with GM2A polyclonal antibody (Cat # PAB19672) (1 mg/mL) in lane 2. Primary incubations were for 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GM2A.
Immunogen
A synthetic peptide corresponding to amino acids 179-189 at internal region of human GM2A.
Sequence
KRLGCIKIAAS
Host
Goat
Theoretical MW (kDa)
28
Reactivity
Human
Specificity
This antibody is expected to recognize isoform 1 (NP_000396.2) only.
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
ELISA (1:4000)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human GM2A with DYKDDDDK tag probed with GM2A polyclonal antibody (Cat # PAB19672) (1.0 ug/mL) in lane 1 and probed with anti- DYKDDDDK Tag (1/30000) in lane 3. Mock-transfected HEK293 probed with GM2A polyclonal antibody (Cat # PAB19672) (1 mg/mL) in lane 2. Primary incubations were for 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GM2A
Entrez GeneID
2760Protein Accession#
NP_000396.2Gene Name
GM2A
Gene Alias
SAP-3
Gene Description
GM2 ganglioside activator
Omim ID
272750Gene Ontology
HyperlinkGene Summary
This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. [provided by RefSeq
Other Designations
cerebroside sulfate activator protein|sphingolipid activator protein 3
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Interactome
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Pathway
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Disease
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