SIRT1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
SIRT1 polyclonal antibody (Cat # PAB19664) (0.05 ug/mL) staining of Jurkat lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SIRT1.
Immunogen
A synthetic peptide corresponding to amino acids 577-590 at internal region of human SIRT1.
Sequence
C-EKPQEVQTSRNVES
Host
Goat
Theoretical MW (kDa)
81.7
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_036370.2; NP_001135970.1).
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
ELISA (1:64000)
Western Blot (0.05-0.2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
SIRT1 polyclonal antibody (Cat # PAB19664) (0.05 ug/mL) staining of Jurkat lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SIRT1
Entrez GeneID
23411Protein Accession#
NP_036370.2;NP_001135970.1Gene Name
SIRT1
Gene Alias
SIR2L1
Gene Description
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Omim ID
604479Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000019691|OTTHUMP00000060745|SIR2alpha|sir2-like 1|sirtuin 1|sirtuin type 1
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Interactome
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Disease
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