Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

KEAP1 polyclonal antibody (Cat # PAB19638) (3.8 ug/mL) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Immunofluorescence

KEAP1 polyclonal antibody (Cat # PAB19638) Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (5 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing nuclear and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (5 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

9817

Protein Accession#

NP_036421.2

Gene Name

KEAP1

Gene Alias

INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454

Gene Description

kelch-like ECH-associated protein 1

Omim ID

606016

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq

Other Designations

cytosolic inhibitor of Nrf2