SOD2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SOD2.
Immunogen
A synthetic peptide corresponding to amino acids 119-130 at internal region of human SOD2.
Sequence
C-EAIKRDFGSFDK
Host
Goat
Theoretical MW (kDa)
24.8, 24.6
Reactivity
Human, Mouse, Rat
Specificity
The immunizing peptide represents the acetylation site including K122 according to isoform A. This antibody is expected to recognize both reported isoforms (NP_000627.2; NP_001019637.1).
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
Western Blot (0.01-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SOD2 polyclonal antibody (Cat # PAB19634) (0.1 ug/mL) staining of mouse spinal cord lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SOD2
Entrez GeneID
6648Protein Accession#
NP_000627.2;NP_001019637.1Gene Name
SOD2
Gene Alias
IPO-B, MNSOD, Mn-SOD
Gene Description
superoxide dismutase 2, mitochondrial
Omim ID
147460Gene Ontology
HyperlinkGene Summary
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
Mn superoxide dismutase|OTTHUMP00000017530|OTTHUMP00000017531|indophenoloxidase B|manganese superoxide dismutase|manganese-containing superoxide dismutase|mangano-superoxide dismutase
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Interactome
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Disease
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Publication Reference
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Dried plum and chokeberry ameliorate d-galactose-induced aging in mice by regulation of Pl3k/Akt-mediated Nrf2 and Nf-kB pathways.
Jeong H, Liu Y, Kim HS.
Experimental Gerontology 2017 May; 95:16.
Application:WB-Ti, Mouse, Mouse liver.
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Dried plum and chokeberry ameliorate d-galactose-induced aging in mice by regulation of Pl3k/Akt-mediated Nrf2 and Nf-kB pathways.
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