Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ZIC3 polyclonal antibody (Cat # PAB1954), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq
OTTHUMP00000024142,heterotaxy 1,zinc finger protein of the cerebellum 3