Fig. A. Colocalization between endogenous CDC42BPA (red) and transferrin-Dyomics 547 (green) after 10 min. incubation of the cells with transferrin-Dyomics 547. Immunostaining with CDC42BPA polyclonal antibody (Cat # PAB19537). Fig. B. Colocalization between endogenous CDC42BPA (red) and transfected MRCK-EGFP (green). Immunostaining with CDC42BPA polyclonal antibody (Cat # PAB19537).
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq
CDC42 binidng protein kinase beta,CDC42-binding protein kinase alpha,CDC42-binding protein kinase alpha (DMPK-like),OTTHUMP00000035727,OTTHUMP00000035728,myotonic dystrophy kinase-related CDC42-binding protein kinase alpha,ser-thr protein kinase PK428,ser