DES polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of DES polyclonal antibody (Cat # PAB1953) in NCI-H460 cell line lysates (35 ug/lane).DES (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocarcinomareacted with DES polyclonal antibody (Cat # PAB1953), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DES.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding T16 of human DES.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of DES polyclonal antibody (Cat # PAB1953) in NCI-H460 cell line lysates (35 ug/lane).DES (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocarcinomareacted with DES polyclonal antibody (Cat # PAB1953), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — DES
Entrez GeneID
1674Protein Accession#
NP_001918;P17661Gene Name
DES
Gene Alias
CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793
Gene Description
desmin
Gene Ontology
HyperlinkGene Summary
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq
Other Designations
OTTHUMP00000064865|intermediate filament protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Desmin myopathy: a multisystem disorder involving skeletal, cardiac, and smooth muscle.
Ariza A, Coll J, Fernandez-Figueras MT, Lopez MD, Mate JL, Garcia O, Fernandez-Vasalo A, Navas-Palacios JJ.
Human Pathology 1995 Sep; 26(9):1032.
Application：IHC-Fr, Human, Deltoid muscle biopsy specimen.
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Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development.
Li ZL, Lilienbaum A, Butler-Browne G, Paulin D.
Gene 1989 May; 78(2):243.
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Desmin myopathy: a multisystem disorder involving skeletal, cardiac, and smooth muscle.
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