THBS2 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of THBS2.
Immunogen
A synthetic peptide corresponding to amino acids at middle region of human THBS2.
Host
Rabbit
Reactivity
Human
Specificity
It different from the mouse sequence by two amino acids.
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of whole cell extracts with THBS2 polyclonal antibody (Cat # PAB19523).
Lane 1, SMMC
Lane 2, MCF-7
Lane 3, HT1080
Lane 4, JurkatImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human placenta tissue with THBS2 polyclonal antibody (Cat # PAB19523) at 1ug/mL. -
Gene Info — THBS2
Entrez GeneID
7058Gene Name
THBS2
Gene Alias
TSP2
Gene Description
thrombospondin 2
Omim ID
188061Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq
Other Designations
OTTHUMP00000042899
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Thrombospondin enhances RANKL-dependent osteoclastogenesis and facilitates lung cancer bone metastasis.
Wang M, Chao CC, Chen PC, Liu PI, Yang YC, Su CM, Huang WC, Tang CH.
Biochemical Pharmacology 2019 Aug; 166:23.
Application:IHC, WB-Ce, WB-Ti, Human, A-549, CL1-0, CL1-5 cells, Human lung cancer.
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Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression.
Chen PC, Tang CH, Lin LW, Tsai CH, Chu CY, Lin TH, Huang YL.
Journal of Hematology & Oncology 2017 Jan; 10(1):33.
Application:IHC-P, WB, Human, Mouse, DU 145, PC-3 cells, Human prostate cancer, Mouse tibia.
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Thrombospondin enhances RANKL-dependent osteoclastogenesis and facilitates lung cancer bone metastasis.
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