Products

Western Blot (Transfected lysate)

Western blot analysis of DAAM1 (arrow) using DAAM1 polyclonal antibody (Cat # PAB1951). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DAAM1 gene (Lane 2) (Origene Technologies).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human brain tissue reacted with DAAM1 polyclonal antibody (Cat # PAB1951) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Entrez GeneID

23002

Protein Accession#

NP_055807;Q9Y4D1

Gene Name

DAAM1

Gene Alias

FLJ41657, KIAA0666

Gene Description

dishevelled associated activator of morphogenesis 1

Omim ID

606626

Gene Ontology

Hyperlink

Gene Summary

Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined. [provided by RefSeq

Other Designations

OTTHUMP00000179033|dishevelled-associated activator of morphogenesis 1