ERVWE1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western Blot analysis of lysate from human brain tissue lysate with ERVWE1 polyclonal antibody (Cat # PAB1950), was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug per lane.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ERVWE1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 400-429 at internal region of human ERVWE1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of lysate from human brain tissue lysate with ERVWE1 polyclonal antibody (Cat # PAB1950), was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug per lane. -
Gene Info — ERVWE1
Entrez GeneID
30816Protein Accession#
NP_055405; Q9UQF0Gene Name
ERVWE1
Gene Alias
Env-W, HERV-7q, HERV-W, HERV-W-ENV, HERVW, env, syncytin
Gene Description
endogenous retroviral family W, env(C7), member 1
Omim ID
604659Gene Ontology
HyperlinkGene Summary
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The product of this gene, syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
HERV-7q envelope protein|HERV-W Env glycoprotein|HERV-W{7q21.1} provirus ancestral Env polyprotein|HERV-tryptophan envelope protein|OTTHUMP00000161914|envelope glycoprotein|envelope protein|enverin|syncytin|syncytin-1
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Disease
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Publication Reference
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Is galectin-1 a trigger for trophoblast cell fusion?: the MAP-Kinase pathway and syncytium formation in trophoblast tumor cells BeWo.
Fischer I, Weber M, Kuhn C, Fitzgerald JS, Schulze S, Friese K, Walzel H, Markert UR, Jeschke U.
Molecular Human Reproduction 2011 Dec; 17(12):747.
Application：IF, Human, BeWo cells.
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Stimulation of Syncytium Formation in vitro in Human Trophoblast Cells by Galectin-1.
Fischer I, Redel S, Hofmann S, Kuhn C, Friese K, Walzel H, Jeschke U.
Placenta 2010 Sep; 31(9):825.
Application：IF, Human, BeWo cells.
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Is galectin-1 a trigger for trophoblast cell fusion?: the MAP-Kinase pathway and syncytium formation in trophoblast tumor cells BeWo.
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