CASP1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of whole cell extracts with CASP1 polyclonal antibody (Cat # PAB19492).
Lane 1, NIH/3T3
Lane 2, MCF-7
Lane 3, HeLa
Lane 4, SMMC
Lane 5, HT1080
Lane 6, SW620
Lane 7, Jurkat
Lane 8, Raji
Lane 9, CEM
Lane 10, PC-12
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human breast cancer tissue section with CASP1 polyclonal antibody (Cat # PAB19492).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASP1.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human CASP1.
Host
Rabbit
Reactivity
Human
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of whole cell extracts with CASP1 polyclonal antibody (Cat # PAB19492).
Lane 1, NIH/3T3
Lane 2, MCF-7
Lane 3, HeLa
Lane 4, SMMC
Lane 5, HT1080
Lane 6, SW620
Lane 7, Jurkat
Lane 8, Raji
Lane 9, CEM
Lane 10, PC-12Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded human breast cancer tissue section with CASP1 polyclonal antibody (Cat # PAB19492). -
Gene Info — CASP1
Entrez GeneID
834Gene Name
CASP1
Gene Alias
ICE, IL1BC, P45
Gene Description
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Omim ID
147678Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
CASP1 nirs variant 1|IL1B-convertase|caspase 1|caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)|interleukin 1-B converting enzyme|interleukin 1-beta convertase
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Interactome
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Pathway
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Disease
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