MSX2 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of MSX2 (arrow) using MSX2 polyclonal antibody (Cat # PAB1949). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MSX2 gene (Lane 2) (Origene Technologies).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MSX2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MSX2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of MSX2 (arrow) using MSX2 polyclonal antibody (Cat # PAB1949). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MSX2 gene (Lane 2) (Origene Technologies). -
Gene Info — MSX2
Entrez GeneID
4488Protein Accession#
NP_002440;P35548Gene Name
MSX2
Gene Alias
CRS2, FPP, HOX8, MSH, PFM, PFM1
Gene Description
msh homeobox 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq
Other Designations
msh homeo box 2|msh homeobox homolog 2
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Interactome
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Disease
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Publication Reference
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Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification.
Shao JS, Aly ZA, Lai CF, Cheng SL, Cai J, Huang E, Behrmann A, Towler DA.
Annals of the New York Academy of Sciences 2007 Nov; 1117:40.
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Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development.
Han J, Ishii M, Bringas P Jr, Maas RL, Maxson RE Jr, Chai Y.
Mechanisms of Development 2007 Jul; 124(9-10):729.
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A novel mutation in the MSX2 homeobox gene of a family with foramina parietalia permagna, headache and vascular anomaly.
Ghassibe M, Bernier V, Boon LM, Vikkula M.
European Journal of Pediatrics 2006 Apr; 165(10):734.
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Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification.
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