Western blot analysis of MSX2 (arrow) using MSX2 polyclonal antibody (Cat # PAB1949). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MSX2 gene (Lane 2) (Origene Technologies).
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq