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DYRK1A polyclonal antibody

  • Catalog # : PAB19417
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of DYRK1A.
  • Immunogen:
  • A synthetic peptide corresponding to 17 amino acids near C-terminus of human DYRK1A.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members.
  • Form:
  • Liquid
  • Purification:
  • Peptide affinity purification
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Western Blot (1-2 ug/mL)
    Immunocytochemistry (10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • 1.
  • Impact of Dyrk1A level on alcohol metabolism.
    Renon M, Legrand B, Blanc E, Daubigney F, Bokobza C, Mortreux M, Paul J, Delabar J, Rouach H, Andreau K, Janel N.Biochimica et Biophysica Acta - Molecular Basis of Disease. 2016 May 20. [Epub ahead of print]
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of DYRK1A in HeLa cell lysate with DYRK1A polyclonal antibody (Cat # PAB19417) at 1 ug/mL (lane 1) and 2 ug/mL (lane 2).
  • Immunocytochemistry
  • Immunocytochemistry
  • Immunocytochemical staining of HeLa cells with DYRK1A polyclonal antibody (Cat # PAB19417) at 10 ug/mL.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1859
  • Gene Name:
  • DYRK1A
  • Gene Alias:
  • Gene Description:
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
  • Gene Summary:
  • This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq
  • Other Designations:
  • MNB/DYRK protein kinase,OTTHUMP00000109090,dual specificity YAK1-related kinase,minibrain homolog,mnb protein kinase homolog hp86,protein kinase minibrain homolog,serine/threonine kinase MNB,serine/threonine-specific protein kinase
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