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Last updated: 2017/11/19

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AXIN2 polyclonal antibody

  • Catalog # : PAB19407
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of AXIN2.
  • Immunogen:
  • A synthetic peptide corresponding to 20 amino acids near C-terminus of human AXIN2.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • AXIN2 antibody is predicted to not cross-react with AXIN2. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four.
  • Form:
  • Liquid
  • Purification:
  • Peptide affinity purification
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    Immunohistochemistry (5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of AXIN2 in mouse lung tissue lysate with AXIN2 polyclonal antibody (Cat # PAB19407) at 1 ug/mL.
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical staining of rat lung cells with AXIN2 polyclonal antibody (Cat # PAB19407) at 5 ug/mL.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8313
  • Gene Name:
  • AXIN2
  • Gene Alias:
  • AXIL,DKFZp781B0869,MGC10366,MGC126582
  • Gene Description:
  • axin 2
  • Gene Summary:
  • The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq
  • Other Designations:
  • conductin
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