NUMB polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of NUMB in mouse lung tissue lysate with NUMB polyclonal antibody (Cat # PAB19370) at (1) 0.25 and (2) 0.5 ug/mL.
Immunohistochemistry
Immunohistochemical staining of human lung cells with NUMB polyclonal antibody (Cat # PAB19370) at 5 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NUMB.
Immunogen
A synthetic peptide corresponding to 17 amino acids near C-terminus of human NUMB.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
At least four isoforms of NUMB are known to exist; this antibody will detect all of them.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (0.25-0.5 ug/mL)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of NUMB in mouse lung tissue lysate with NUMB polyclonal antibody (Cat # PAB19370) at (1) 0.25 and (2) 0.5 ug/mL.Immunohistochemistry
Immunohistochemical staining of human lung cells with NUMB polyclonal antibody (Cat # PAB19370) at 5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NUMB
Entrez GeneID
8650Protein Accession#
NP_1005743Gene Name
NUMB
Gene Alias
S171
Gene Description
numb homolog (Drosophila)
Omim ID
603728Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
numb homolog
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Interactome
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Pathway
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Disease
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