AXIN1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of AXIN1 in SK-N-SH cell lysate with AXIN1 polyclonal antibody (Cat # PAB19323) at 1 ug/mL.
Immunofluorescence
Immunofluorescencent staining of human brain cells with AXIN1 polyclonal antibody (Cat # PAB19323) at 20 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody rasied against synthetic peptide of AXIN1.
Immunogen
A synthetic peptide corresponding to 14 amino acids near C-terminus of human AXIN1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1-2 ug/mL)
Immunofluorescence (20 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of AXIN1 in SK-N-SH cell lysate with AXIN1 polyclonal antibody (Cat # PAB19323) at 1 ug/mL.Immunofluorescence
Immunofluorescencent staining of human brain cells with AXIN1 polyclonal antibody (Cat # PAB19323) at 20 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AXIN1
Entrez GeneID
8312Protein Accession#
AAC51624Gene Name
AXIN1
Gene Alias
AXIN, MGC52315
Gene Description
axin 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
axis inhibition protein 1|axis inhibitor 1|fused, mouse, homolog of
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Interactome
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Pathway
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Disease
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