CIITA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody rasied against synthetic peptide of CIITA.
Immunogen
A synthetic peptide corresponding to 16 amino acids near N-terminus of human CIITA.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CIITA in mouse brain tissue lysate with CIITA polyclonal antibody (Cat # PAB19313) at 1 ug/mL.Immunohistochemistry
Immunohistochemical staining of human brain cells with CIITA polyclonal antibody (Cat # PAB19313) at 10 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CIITA
Entrez GeneID
4261Protein Accession#
P33076Gene Name
CIITA
Gene Alias
C2TA, CIITAIV, MHC2TA, NLRA
Gene Description
class II, major histocompatibility complex, transactivator
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq
Other Designations
MHC class II transactivator type III|NLR family, acid domain containing|class II transactivator|nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
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Interactome
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