CDC27 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of mouse liver tissue with CDC27 polyclonal antibody (Cat # PAB19233) at (Lane 1) 1 and (Lane 2) 2 ug/mL dilution.
Immunohistochemistry
Immunohistochemical staining of rat liver tissue with CDC27 polyclonal antibody (Cat # PAB19233) at 5 ug/mL dilution.
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Specification
Product Description
Rabbit polyclonal antibody rasied against synthetic peptide of CDC27.
Immunogen
A synthetic peptide corresponding to 19 amino acids near C-terminus of human CDC27.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse liver tissue with CDC27 polyclonal antibody (Cat # PAB19233) at (Lane 1) 1 and (Lane 2) 2 ug/mL dilution.Immunohistochemistry
Immunohistochemical staining of rat liver tissue with CDC27 polyclonal antibody (Cat # PAB19233) at 5 ug/mL dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDC27
Entrez GeneID
996Protein Accession#
NP_001247Gene Name
CDC27
Gene Alias
APC3, CDC27Hs, D0S1430E, D17S978E, HNUC
Gene Description
cell division cycle 27 homolog (S. cerevisiae)
Omim ID
116946Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
anaphase-promoting complex, protein 3|cell division cycle protein 27|nuc2 homolog
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Interactome
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Pathway
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