MAP2K3 polyclonal antibody
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More Files
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Western Blot
Western blot analysis of tissue and whole cell extracts with MAP2K3 polyclonal antibody (Cat # PAB19110).
Lane 1 : rat spleen. Lane 2 : rat thymus. Lane 3 : rat skeletal muscle. Lane 4 : rat kidney.
Lane 5 : MCF-7. Lane 6 : HeLa. Lane 7 : Raji. Lane 8 : CEM. Lane 9 : Colo 320 HSR.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP2K3.
Immunogen
A synthetic peptide corresponding to C-terminus of human MAP2K3.
Host
Rabbit
Reactivity
Human, Rat
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
Immunocytochemistry (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of tissue and whole cell extracts with MAP2K3 polyclonal antibody (Cat # PAB19110).
Lane 1 : rat spleen. Lane 2 : rat thymus. Lane 3 : rat skeletal muscle. Lane 4 : rat kidney.
Lane 5 : MCF-7. Lane 6 : HeLa. Lane 7 : Raji. Lane 8 : CEM. Lane 9 : Colo 320 HSR.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
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Gene Info — MAP2K3
Entrez GeneID
5606Gene Name
MAP2K3
Gene Alias
MAPKK3, MEK3, MKK3, PRKMK3
Gene Description
mitogen-activated protein kinase kinase 3
Omim ID
602315Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq
Other Designations
MAP kinase kinase 3|MAPK/ERK kinase 3|OTTHUMP00000166044|dual specificity mitogen activated protein kinase kinase 3
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