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PSEN2 polyclonal antibody

  • Catalog # : PAB19096
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PSEN2.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human PSEN2.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Rat
  • Form:
  • Lyophilized
  • Purification:
  • Immunoaffinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
    Immunohistochemistry (Frozen sections) (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of tissue and whole cell extracts with PSEN2 polyclonal antibody (Cat # PAB19096).
    Lane 1 : rat brain.
    Lane 2 : MCF-7. Lane 3 : HeLa. Lnae 4 : SMMC. Lane 5 : CEM.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of rat brain tissue with PSEN2 polyclonal antibody (Cat # PAB19096).
  • Immunohistochemistry (Frozen sections)
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Frozen sections)
  • Gene Information
  • Entrez GeneID:
  • 5664
  • Gene Name:
  • PSEN2
  • Gene Alias:
  • AD3L,AD4,PS2,STM2
  • Gene Description:
  • presenilin 2 (Alzheimer disease 4)
  • Gene Summary:
  • Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq
  • Other Designations:
  • Alzheimer's disease 3-like,OTTHUMP00000035671,presenilin 2
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