Western blot analysis of tissue and whole cell extracts with STK11 polyclonal antibody (Cat # PAB19093). Lane 1 : rat testis. Lane 2 : rat liver. Lane 3 : rat lung. Lane 4 : rat embryo. Lane 5 : MM453 cells. Lane 6 : HeLa cells. Lane 7 : SMMC cells.
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
polarization-related protein LKB1,serine/threonine protein kinase 11