BCL2A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
BCL2A1 polyclonal antibody (Cat # PAB19064) (0.2 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of BCL2A1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human BCL2A1.
Sequence
C-NVVSVDTART
Host
Goat
Theoretical MW (kDa)
20
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
BCL2A1 polyclonal antibody (Cat # PAB19064) (0.2 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BCL2A1
Entrez GeneID
597Protein Accession#
NP_004040.1;NP_001108207.1Gene Name
BCL2A1
Gene Alias
ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1
Gene Description
BCL2-related protein A1
Omim ID
601056Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
hematopoietic BCL2-related protein A1
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Interactome
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Pathway
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Disease
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