Products

Western Blot (Transfected lysate)

HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human CST8 with C-terminal MYC tag probed with CST8 polyclonal antibody (Cat # PAB19022) (1 ug/mL) in Lane 1 and probed with anti-MYC Tag (1/1000) in Lane 3. Mock-transfected HEK293 probed with CST8 polyclonal antibody (Cat # PAB19022) (1 mg/mL) in Lane 2. Primary incubations were for 1 hour. Detected by chemiluminescence.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

10047

Protein Accession#

NP_005483.1

Gene Name

CST8

Gene Alias

CRES

Gene Description

cystatin 8 (cystatin-related epididymal specific)

Omim ID

608683

Gene Ontology

Hyperlink

Gene Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of putative variants has not been determined. [provided by RefSeq

Other Designations

OTTHUMP00000030434|cystatin 8|cystatin-related epididymal spermatogenic protein|cystatin-related epididymal-specific