TIAL1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
TIAL1 polyclonal antibody (Cat # PAB19020) (2 ug/mL) staining of K-562 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human skin with TIAL1 polyclonal antibody (Cat # PAB19020) (3.8 ug/mL). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TIAL1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human TIAL1.
Sequence
C-SPEITTEDIKSAFAP
Host
Goat
Theoretical MW (kDa)
45
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)(3-5 ug/mL)
ELISA (1:64000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
TIAL1 polyclonal antibody (Cat # PAB19020) (2 ug/mL) staining of K-562 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human skin with TIAL1 polyclonal antibody (Cat # PAB19020) (3.8 ug/mL). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TIA1
Entrez GeneID
7072Protein Accession#
NP_003243.1 (Gene ID : 7073);NP_001029097.1 (Gene ID : 7073)Gene Name
TIA1
Gene Alias
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Gene Description
TIA1 cytotoxic granule-associated RNA binding protein
Omim ID
603518Gene Ontology
HyperlinkGene Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq
Other Designations
T-cell-restricted intracellular antigen-1|TIA1 cytotoxic granule-associated RNA-binding protein|TIA1 protein|cytotoxic granule-associated RNA-binding protein|nucleolysin TIA-1 isoform p40|p40-TIA-1 (containing p15-TIA-1)
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Gene Info — TIAL1
Entrez GeneID
7073Protein Accession#
NP_003243.1 (Gene ID : 7073);NP_001029097.1 (Gene ID : 7073)Gene Name
TIAL1
Gene Alias
MGC33401, TCBP, TIAR
Gene Description
TIA1 cytotoxic granule-associated RNA binding protein-like 1
Omim ID
603413Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq
Other Designations
OTTHUMP00000020602|OTTHUMP00000020605|T-cluster binding protein|TIA-1 related protein|TIA-1-related nucleolysin|TIA1 cytotoxic granule-associated RNA-binding protein-like 1|aging-associated gene 7 protein
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Interactome
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