HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human HOXA1 with C-terminal MYC tag probed with HOXA1 polyclonal antibody (Cat # PAB19019) (1 ug/mL) in Lane 1 and probed with anti-MYC Tag (1/1000) in lane 3. Mock-transfected HEK293 probed with HOXA1 polyclonal antibody (Cat # PAB19019) (1 mg/mL) in Lane 2. Primary incubations were for 1 hour. Detected by chemiluminescence.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq
HOX A1 homeodomain protein,Hox 1.6-like protein,homeo box A1,homeobox 1F,homeobox protein HOX-A1,lab-like protein