GRM2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
GRM2 polyclonal antibody (Cat # PAB19004, 1 ug/mL) staining of human hippocampus lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
GRM2 polyclonal antibody (Cat # PAB19004) (3.8 ug/mL) staining of paraffin embedded human cerebral cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GRM2.
Immunogen
A synthetic peptide corresponding to internal region of human GRM2.
Sequence
C-KETAPERREV
Host
Goat
Theoretical MW (kDa)
30
Reactivity
Human
Specificity
This antibody is expected to recognize both isoforms (NP_000830.2; NP_001123535.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GRM2 polyclonal antibody (Cat # PAB19004, 1 ug/mL) staining of human hippocampus lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
GRM2 polyclonal antibody (Cat # PAB19004) (3.8 ug/mL) staining of paraffin embedded human cerebral cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRM2
Entrez GeneID
2912Protein Accession#
NP_000830.2;NP_001123535.1Gene Name
GRM2
Gene Alias
GLUR2, GPRC1B, MGLUR2, mGlu2
Gene Description
glutamate receptor, metabotropic 2
Omim ID
604099Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
glutamate metabotropic receptor 2|glutamate receptor homolog
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Interactome
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Pathway
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Disease
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