CYP24A1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
CYP24A1 polyclonal antibody (Cat # PAB18975, 0.1 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CYP24A1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human CYP24A1.
Sequence
C-RKYDIQATDN
Host
Goat
Theoretical MW (kDa)
50
Reactivity
Human, Rat
Specificity
This antibody is expected to recognize both reported isoforms (NP_000773.2; NP_001122387.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL in Tris saline, pH7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CYP24A1 polyclonal antibody (Cat # PAB18975, 0.1 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYP24A1
Entrez GeneID
1591Protein Accession#
NP_000773.2;NP_001122387.1Gene Name
CYP24A1
Gene Alias
CP24, CYP24, MGC126273, MGC126274, P450-CC24
Gene Description
cytochrome P450, family 24, subfamily A, polypeptide 1
Omim ID
126065Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
1,25-@dihydroxyvitamin D3 24-hydroxylase|24-OHase|OTTHUMP00000031314|cytochrome P450 family 24 subfamily A polypeptide 1|cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase)|exo-mitochondrial protein|vitamin D 24-hydroxylase
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Interactome
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Disease
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Publication Reference
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Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats.
Reis NG, Francescato HDC, de Almeida LF, Silva CGAD, Costa RS, Coimbra TM.
Scientific Reports 2019 May; 9(1):7090.
Application：WB-Ti, Rat, Rat renal cortex.
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Protective effect of calcitriol on rhabdomyolysis-induced acute kidney injury in rats.
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