PCSK9 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human PCSK9 with C-terminal MYC tag probed with PCSK9 polyclonal antibody (Cat # PAB18962, 1 ug/mL) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with PCSK9 polyclonal antibody (Cat # PAB18962, 1 mg/mL) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PCSK9.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human PCSK9.
Sequence
TRFHRQASKCDSHGT
Host
Goat
Theoretical MW (kDa)
80-100
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (0.1-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL in Tris saline, pH7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human PCSK9 with C-terminal MYC tag probed with PCSK9 polyclonal antibody (Cat # PAB18962, 1 ug/mL) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with PCSK9 polyclonal antibody (Cat # PAB18962, 1 mg/mL) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PCSK9
Entrez GeneID
255738Protein Accession#
NP_777596.2Gene Name
PCSK9
Gene Alias
FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1
Gene Description
proprotein convertase subtilisin/kexin type 9
Gene Ontology
HyperlinkGene Summary
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq
Other Designations
OTTHUMP00000009833|convertase subtilisin/kexin type 9 preproprotein|neural apoptosis regulated convertase 1
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Interactome
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Disease
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