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Last updated: 2016/10/23
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GNB3 polyclonal antibody

  • Catalog # : PAB18952
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of GNB3.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids at internal region of human GNB3.
  • Sequence:
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 35
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is expected to recognize GNB3 & GNB4 (GeneID: 2784, 59345; ProteinID: NP_002066.1; NP_067642.1).
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:16000)
    Western Blot (0.1-0.3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 0.5 mg/mL in Tris saline, pH7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • GNB3 polyclonal antibody (Cat # PAB18952, 0.1 ug/mL) staining of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 2784
  • Protein Accession#:
  • NP_002066.1;NP_067642.1
  • Gene Name:
  • GNB3
  • Gene Alias:
  • -
  • Gene Description:
  • guanine nucleotide binding protein (G protein), beta polypeptide 3
  • Gene Summary:
  • Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. [provided by RefSeq
  • Other Designations:
  • G protein, beta-3 subunit,GTP-binding regulatory protein beta-3 chain,guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3,guanine nucleotide-binding protein, beta-3 subunit,hypertension associated protein,transducin beta chain 3
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