CSF1R polyclonal antibody
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More Files
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Western Blot (Transfected lysate)
HEK293 lysate (10ug protein in RIPA buffer) overexpressing human CSF1R with C-terminal MYC tag probed with CSF1R polyclonal antibody (Cat # PAB18945, 1 ug/mL) in Lane A and probed with anti-MYC Tag (1/1000) in lane C.
Mock-transfected HEK293 probed with CSF1R polyclonal antibody (Cat # PAB18945) (1 mg/mL) in Lane B.
Primary incubations were for 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CSF1R.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human CSF1R.
Sequence
C-NDSFSEQDLDK
Host
Goat
Theoretical MW (kDa)
200
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (0.2-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL in Tris saline, pH7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 lysate (10ug protein in RIPA buffer) overexpressing human CSF1R with C-terminal MYC tag probed with CSF1R polyclonal antibody (Cat # PAB18945, 1 ug/mL) in Lane A and probed with anti-MYC Tag (1/1000) in lane C.
Mock-transfected HEK293 probed with CSF1R polyclonal antibody (Cat # PAB18945) (1 mg/mL) in Lane B.
Primary incubations were for 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CSF1R
Entrez GeneID
1436Protein Accession#
NP_005202.2Gene Name
CSF1R
Gene Alias
C-FMS, CD115, CSFR, FIM2, FMS
Gene Description
colony stimulating factor 1 receptor
Omim ID
164770Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq
Other Designations
CD115 antigen|FMS proto-oncogene|McDonough feline sarcoma viral (v-fms) oncogene homolog|macrophage colony stimulating factor I receptor|soluble CSF1R variant 1
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Interactome
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Pathway
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Disease
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