KREMEN1 polyclonal antibody
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More Files
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Western Blot (Transfected lysate)
Western blot analysis of KREMEN1 (arrow) using KREMEN1 polyclonal antibody (Cat # PAB1891). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the KREMEN1 gene (Lane 2) (Origene Technologies).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with KREMEN1 polyclonal antibody (Cat # PAB1891), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KREMEN1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human KREMEN1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of KREMEN1 (arrow) using KREMEN1 polyclonal antibody (Cat # PAB1891). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the KREMEN1 gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with KREMEN1 polyclonal antibody (Cat # PAB1891), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — KREMEN1
Entrez GeneID
83999Protein Accession#
NP_114434Gene Name
KREMEN1
Gene Alias
FLJ31863, KREMEM1, KREMEN, KRM1
Gene Description
kringle containing transmembrane protein 1
Omim ID
609898Gene Ontology
HyperlinkGene Summary
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000028977|kringle-coding gene marking the eye and the nose|kringle-containing transmembrane protein 1
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Interactome
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Disease
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Publication Reference
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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
Mao B, Wu W, Davidson G, Marhold J, Li M, Mechler BM, Delius H, Hoppe D, Stannek P, Walter C, Glinka A, Niehrs C.
Nature 2002 Jun; 417(6889):664.
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Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein.
Nakamura T, Aoki S, Kitajima K, Takahashi T, Matsumoto K, Nakamura T.
Biochimica et Biophysica Acta 2001 Mar; 1518(1-2):63.
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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.
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